The nucleic acid test results of both asymptomatic and confirmed cases of novel coronavirus pneumonia were positive, and the difference between the two was the difference in clinical symptoms and management. 1. Clinical symptoms: Patients with asymptomatic infection of novel coronavirus pneumonia do not have relevant clinical symptoms, and there is no manifestation of novel coronavirus pneumonia on chest imaging. Confirmed cases: According to the severity of the disease, confirmed cases can be classified as mild, common, severe and critical. Patients may have fever, cough, diarrhea, sore throat, etc., and in severe cases, shortness of breath and respiratory distress may also be present. Chest imaging may show interstitial changes and lung parenchymal abnormalities. 2. Treatment: Asymptomatic infected patients generally do not need special treatment, but still need temporary isolation and medical observation, such as regular monitoring of body temperature and nucleic acids. Confirmed cases need to be isolated and treated in designated hospitals with effective isolation and protection conditions, and given effective oxygen therapy and other measures when necessary, and can also be treated with antiviral drugs such as α-interferon nebulized inhalation, ribavirin, chloroquine phosphate, and so on. For patients with severe and critical cases, symptomatic treatment, such as immunotherapy and circulatory support, is needed in conjunction with specific conditions. Both asymptomatic and confirmed cases of novel coronavirus pneumonia should be treated in accordance with medical advice. Tip: In this article, “new coronavirus pneumonia” and “new coronavirus pneumonia” have been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.