If you have pain in the urethra when you urinate, it is recommended that you go to the hospital for an examination to determine the cause and to choose the appropriate medication. First, a physical examination should be conducted to find out whether there is redness or swelling in the urethra and whether there are local ulcers. If there is local ulceration, erosion or redness, it is recommended to use potassium permanganate solution for local cleaning. After cleaning, apply a little bit of Bactrim ointment to the red and swollen area 3 times a day, or a little bit of erythromycin ointment 3 times a day, and observe the improvement of pain. Second, if the physical examination of the urethra is not red, swollen, erosion and other reactions, you need to carry out routine urine examination. If there are more white blood cells in the routine urine, or the bacterial count is significantly elevated, it is recommended to take oral levofloxacin hydrochloride capsule, 1 capsule, 3 times a day for 3-5 days, and observe whether the painful symptoms of the urethra are relieved.