There are many reasons for getting up in the morning with a dry, bitter and smelly mouth, and the treatment and medication are different for different reasons. Such as periodontitis, can choose general treatment (such as control of oral plaque, etc.), if necessary, can also be drug treatment (such as minocycline, etc.); such as dyspepsia, can choose general treatment (such as regular diet, etc.), can also choose medication (such as Moxapride, etc.). 1. Periodontitis: general treatment can be carried out, the main need for its oral plaque control, to maintain local oral hygiene, followed by the distribution of tartar according to the location of the tartar, take the gingival cleaning method or subgingival scraping method to remove tartar. If necessary, medication can also be carried out, such as minocycline, amoxicillin and other antibiotic drugs to eliminate pathogenic bacteria, so as to achieve the therapeutic effect. 2. indigestion: general treatment can be carried out, three meals a day regular diet, avoid staying up late, more physical exercise, etc.; can also be treated with medication, taking omeprazole, mosapride and other drugs, effective inhibition of gastric acid secretion, to promote gastrointestinal dynamics, so as to achieve the therapeutic purpose. Appeared in the morning get up mouth dry bitter odor of the situation, should be timely medical treatment, under the guidance of the doctor for targeted treatment, so as not to delay the condition.