Due to individual differences, the safest NSAIDs for pain relief do not exist. NSAIDs have antipyretic, analgesic, anti-inflammatory, platelet aggregation inhibiting, anti-rheumatic effects, etc. Commonly used drugs include aspirin, acetaminophen, diclofenac sodium, loxoprofen sodium, ibuprofen, celecoxib, etc. In terms of pain relief, they have only moderate analgesic effects, and are effective for headache, toothache, joint pain, muscle pain, menstrual pain, as well as moderate postoperative pain and the initial stage of tumor pain, but are ineffective for smooth muscle spasm pain, severe traumatic pain, and severe pain in the late stage of tumor. NSAIDs can cause adverse reactions such as nausea, vomiting, gastrointestinal mucosal damage, liver and kidney function damage. In addition, some patients may also have allergies, so there is no such thing as which one is safer, and the clinical use process requires weighing the pros and cons according to the patient’s condition and using them after comprehensive judgment.