Pulmonary artery segment protrusion is usually a diagnosis of pulmonary artery segment depression on radiographs. The main manifestation of pulmonary artery segment protrusion is generally pulmonary hypertension, where the pressure in the pulmonary artery is continuously elevated, resulting in the expansion of the pulmonary artery segment, which appears as a prominent depressed foci on the radiographs. The presence of pulmonary hypertension generally requires active knowledge of the primary condition, such as congenital heart disease, right-to-left shunt, Eisenmenger syndrome or patent ductus arteriosus, triad of Fallot, or even heart valve disease, which may cause pulmonary artery protrusion and pulmonary artery hypertension. This requires active treatment of the primary disease, as well as treatment with drugs that lower pulmonary pressure.