What antibiotics are effective for lung infections need to be decided according to the pathogenetic examination of lung infections. Generally, lobar pneumonia is mainly due to Streptococcus pneumoniae infection, and penicillin antibiotics are preferred, including penicillin, amoxicillin, as well as piperacillin and benzathine penicillin, and so on. If the lung infection is due to Staphylococcus aureus infection, resulting in multiple infected foci in both lungs, erythromycin antibiotics, including azithromycin, are given to effectively control the Staphylococcus aureus infection. And if the lung infection is caused by fungus, voriconazole, micafungin, caspofungin and other medications need to be given. In conclusion, what antibiotics to use for lung infection is best chosen based on the results of bacterial culture, and empirical use of antibiotics is only considered if the bacterial culture results are negative.