Tooth blisters may be caused by chronic periapical disease, periodontal disease and other breakthroughs in the gums to form a fistula, treatment methods include drug treatment, surgical treatment and so on. 1. Chronic periapical disease: this disease can cause gingival fistula, the above symptoms. (1) Anti-infection treatment: such as oral anti-inflammatory drugs cephalosporin, cefixime, metronidazole, etc., or taking acetylspiramycin or roxithromycin. (2) Root canal treatment: can completely eliminate the gingival fistula. 2. Periodontal disease: the prolongation of the disease can also cause the above symptoms. (1) Remove local irritation: such as removing granulation tissue, tartar, bad restorations, etc., rinse the periodontium with hydrogen peroxide solution and apply iodophor to reduce inflammation. (2) Drug treatment: use chlorhexidine solution as gargle to control plaque; place tetracycline slow-release gel in periodontal pockets; take oral cephalosporin and other drugs for anti-infection treatment. (3) Surgical treatment: guided tissue regeneration, periodontal flap surgery, etc., together with anti-infective treatment such as cephalosporin. Regular review is recommended. In addition to the above diseases, mucosal herpes, pemphigus and other diseases can also cause the above manifestations. It is recommended to go to the hospital, identify the cause of the disease, and carry out regular treatment under the guidance of the doctor. The above medications are recommended to be applied under the guidance of a doctor or pharmacist, avoiding self-medication to avoid adverse reactions.