Cranial repair surgery is a routine surgery in neurosurgery, but it is not easy to do well. Many large hospitals in many places may be able to carry out skull repair surgery, but most of them use the traditional titanium mesh material, and the technology may not be very sophisticated, and often the repair effect is not very satisfactory, and after the operation, there may be infection, rejection, scalp exposure, collapse and deformation and other problems. Therefore, cranial repair should be more careful, especially to choose the right repair material. Xiao Chen (pseudonym), a 13-year-old girl from Henan Province, recovered well from her cranial defect after undergoing PEEK cranioplasty in the Department of Neurosurgery under the careful treatment of Dr. Zhu. Xiao Chen was involved in a car accident about four months ago and was admitted to the local hospital, where she was diagnosed with right frontal lobe cerebral contusion, right frontal lobe hematoma, right temporal occipital traumatic acute subdural hemorrhage, skull fracture, and scalp laceration by craniectomy, hematoma removal, trauma removal, and scalp closure, which resulted in a cranial defect of about 5 cm*8 cm. Although the area of the defect is not too large, it is also evident that Xiao Chen’s forehead has an obvious collapse. Although the defect area was not too big, it was obvious that Xiao Chen’s forehead had collapsed, which became a deep problem in Xiao Chen’s heart, and she had to wear a hat every time she went out. During the period of cranial defect, Xiao Chen often felt dizzy, and she didn’t dare to do strenuous movements, and she couldn’t go to sports classes, which was very distressing. Later, Xiao Chen’s father learned through various channels that Director Zhu had done a very good job in cranial repair, so he brought his daughter to the hospital. Upon arrival at the hospital, after diagnosis and evaluation, the director arranged for the staff to collect Xiao Chen’s skull 3D CT data for the 3D reconstruction design and production of PEEK repair material. After the material production was completed and delivered to the hospital, the director performed PEEK cranioplasty for Xiao Chen. During the operation, the PEEK repair plate was precisely embedded in the bone window and completed a good physiological and anatomical restoration. The operation was very successful. Xiao Chen’s head was restored to its original appearance, the original forehead of the obvious collapse re-bulging, Xiao Chen face also showed a happy smile. Adopting the very advanced new cranial bone repair material, i.e. polyether ether ketone PEEK material, and constantly improving and upgrading and optimizing the surgical technology and material design, as well as introducing the concept of cosmetic plastic surgery, the PEEK cranial bone repair and reconstructive surgery carried out as a result, which can restore the integrity of the cranial cavity and at the same time, make the patients’ cranial appearance achieve beautiful symmetry, which is recognized and praised by the majority of patients.