With the development of imaging techniques such as magnetic resonance, the diagnosis of gliomas has now become easier. However, not all patients are able to detect the disease in the early stage and go to the hospital for examination, but come to the hospital only when the tumor is already very large. Below are some of the early clinical symptoms of glioma. Symptom 1: Headache About 30% of patients with glioma manifest headache, and about 70% of them will have headache that will get worse gradually. Most of these headaches are not specific, but intermittent, mostly located on the same side of the lesion, manifested as dull pain rather than throbbing pain, sometimes not easy to distinguish from tension headache. Cerebral gliomas usually present with pain in the forehead, while cerebellar gliomas tend to present with pain in the occipital and neck regions. If the tumor is too large and produces high intracranial pressure, the headache is significantly worse, sometimes waking up in pain during sleep and worsening with vigorous head movements, sometimes accompanied by nausea and vomiting. If the intracranial hypertension persists for too long, there may also be a loss of vision. Symptom 2: Seizures About 1/3 of patients with gliomas exhibit seizures, and the incidence increases to 50-70% as the disease progresses. Half of these seizures are limited, while the other half are generalized. Slow-growing, low-grade gliomas are particularly likely to cause seizures, whereas glioblastomas are very unlikely to cause seizures. Oligodendrogliomas cause seizures in about 75 to 95% of cases, astrocytomas in about 65 to 70%, and glioblastomas in about 37 to 50%. High-grade gliomas with seizures tend to have a better prognosis than those without seizures. Different parts of the glioma cause seizures are not the same chance and performance, in addition to can cause generalized grand mal seizure, different parts of the tumor caused by seizures often have their own characteristics: such as frontal lobe glioma can cause contralateral limb seizures and aphasia, etc.; medial temporal lobe tumors are often accompanied by phantom smell, episodic fear and shortness of breath, etc.; and parietal lobe tumors can cause paraplegic sensory deficits and so on. Symptom 3: Mental change About 15-20% of glioma patients have mental status change as the first symptom, which is mainly manifested as changes in mood, personality, cognitive function, memory and so on. Symptom 4: Focal neurological symptoms Different locations of the tumor can also cause corresponding neurological deficit symptoms, such as paralysis of limbs, sensory deficits, aphasia, unsteady gait, dyslexia and dysgraphia. Symptom 5: Cranial nerve symptoms Different cranial nerve damages will produce corresponding neurological symptoms, such as vision loss, diplopia, eyeball strabismus and facial paralysis. Overall, brain glioma can show all the symptoms of neurological diseases, but not all the symptoms will appear in a particular person, and these early symptoms will vary with the type of tumor, tissue characteristics, location and speed of growth. Doctor’s tip: The above symptoms are not only the early clinical symptoms of glioma, but also suitable for many other kinds of brain tumors, if the related obvious symptoms appear, you should go to the hospital as soon as possible.