The causes of acid reflux heartburn are reflux esophagitis, chronic gastritis, gastric ulcer, etc. The drug treatment of the disease should follow the principle of individualization, there is no so-called “special effect drug”, and the patient needs to choose the right drug according to his specific condition. Commonly used drugs for reflux esophagitis include ranitidine, famotidine, omeprazole, lansoprazole, domperidone, mosapride, aluminum thiogluconate, magnesium alumina carbonate, etc. These drugs are used to treat the symptoms by inhibiting acidity, protecting the gastric mucous membrane, and promoting gastric motility. Commonly used drugs for gastritis and gastric ulcer include omeprazole, lansoprazole, amoxicillin, metronidazole, bismuth potassium citrate, bismuth pectin and so on, which are used to treat by inhibiting the secretion of gastric acid, protecting the gastric mucosa, and resisting Helicobacter pylori. Due to the different indications, contraindications and adverse reactions of different drugs, doctors will choose the most suitable drug for treatment according to the severity of the patient’s condition and the therapeutic effect. It is important to note that before using the drugs, one should pay attention to the onset of action and side effects of the drugs used, make good psychological preparation, and increase the adherence to the treatment; at the same time, one should follow the doctor’s instructions to use the drugs, and avoid using the drugs on one’s own.