Taking esomeprazole stomach stuffy pain may be caused by the adverse reaction of the drug, may also be related to the primary disease, the 1. Adverse drug reactions: the common adverse reactions to esomeprazole are headache, diarrhea, nausea, vomiting, constipation, abdominal pain and bloating, etc. Therefore, it is possible to have the symptom of stomach stuffy pain after taking esomeprazole. 2. Acute gastroenteritis: acute gastroenteritis is a viral or bacterial infection caused by acute inflammation of the mucosa of the gastrointestinal tract, patients with acute gastroenteritis simply take esomeprazole can not alleviate the abdominal pain, so there can be the symptoms of eating esomeprazole stomach stuffy pain. 3. bile reflux gastritis: bile reflux gastritis, also known as alkaline reflux gastritis, is a kind of inflammation of the gastric mucosa due to the abnormal reflux of bile into the stomach, when taking esomeprazole to inhibit the secretion of gastric acid, this alkaline reflux will be more strong stimulation to the stomach, so there will be the symptom of eating esomeprazole boring pain in the stomach. To summarize, if esomeprazole can not treat the primary disease, then the symptoms of stomach stuffy pain after taking esomeprazole may still occur, if the patient has the symptoms of stomach stuffy pain after taking esomeprazole, he should consult the doctor in time, ask the doctor to identify the cause and dispose of it.