The main causes of chronic obstructive pulmonary disease are the following: 1, genetic factors: α1-antitrypsin deficiency is related to the formation of emphysema; 2, environmental factors: common in smoking, including second-hand smoke can lead to the occurrence of slow obstructive pulmonary, research found that 80%-90% of patients with slow obstructive pulmonary have a history of smoking; 3, occupational exposure: occupational exposure to dust and harmful gases for too long or exposure concentration Too high exposure can increase airway reactivity, leading to the occurrence of slow lung; 4, cooking fuel: some areas often use biofuels for heating or cooking, the living environment is too narrow, poor air circulation, leading to increased airway reactivity; 5, environmental pollution: increased sulfur dioxide in the air, the formation of damage to the airway; 6, infection: long-term chronic bronchitis repeated infection, repeated airway inflammation, can aggravate or lead to the occurrence of chronic obstructive pulmonary disease.