Taking a cephalosporin at noon and drinking alcohol at night is a matter of extreme importance, and the two may have a disulfiram-like reaction, which can be fatal in severe cases. Cephalosporin is a kind of β-lactam antibiotics, easy and alcohol disulfiram-like reaction, so it is recommended that generally in the 7 ~ 10 days after eating cephalosporin antibiotics try not to drink alcohol, in order to avoid life-threatening. Because alcohol into the blood will and cephalosporin antibiotics disulfiram-like reaction, mainly manifested as headache, dizziness, nausea, vomiting, chest tightness, shortness of breath, dyspnea, drop in blood pressure, weakness of the limbs, facial flushing, etc., and in severe cases, there will be lethargy, hallucinations, respiratory depression and even shock, which may be life-threatening. Cephalosporin at lunchtime and drinking at night can be life-threatening and should be avoided as much as possible. If you have been drinking, we suggest you drink a lot of water and observe the symptoms closely.