Alcohol should not be consumed in H. pylori quadruple therapy, or it may exacerbate the condition, affect the efficacy of the medicine, and even produce disulfiram reaction. 1. Exacerbate the condition: Helicobacter pylori infection can lead to peptic ulcer, chronic gastritis and other diseases, which can lead to different degrees of damage to the gastric mucosa of the organism. Drinking alcohol in this case will stimulate the damaged gastric mucosa and aggravate the condition. 2. Affect the effectiveness of the drug: alcohol and drugs will be metabolized by the liver after entering the human body. Drinking alcohol while taking medication can aggravate the burden on the liver, affecting the decomposition and metabolism of the medication, which in turn affects the efficacy of the medication. 3. Adverse reactions: quadruple drugs include two different antibiotics, such as the application of metronidazole and other drugs during the consumption of alcohol, may also produce disulfiram reaction, endangering the lives of patients. Alcohol consumption should be prohibited during the administration of the drug. For other medication precautions, it is recommended to follow the doctor’s instructions.