Long-term use of ibuprofen extended-release capsules may cause very serious cardiovascular thrombotic events, such as myocardial infarction and stroke. Ibuprofen extended-release capsules can also cause serious gastrointestinal reactions, such as bleeding and ulcers in the gastrointestinal tract, and may even cause perforation. Ibuprofen extended-release capsules can inhibit blood clotting, which is more likely to cause bleeding or bleeding more than once. It is recommended to use measures such as a soft-bristled toothbrush or electric razor during medication to avoid accidental injury. If you experience more severe chest pain, shortness of breath, weakness, and cardiovascular symptoms such as slurred speech, or gastrointestinal reactions such as vomiting blood, black stools, persistent abdominal pain, and abdominal distention while taking Ibuprofen Extended-Release Capsules, discontinue the medication immediately and seek medical attention from a local regular medical institution.