Nausea in the middle of the night may be caused by nervousness, generally no treatment, if the pyloric obstruction, peptic ulcer and other diseases caused by the cause of the need to take medication, surgical treatment. 1. Mental tension: if the recent life stress is too large, the spirit of a long time in a state of tension, anxiety, nausea in the middle of the night is likely to occur, generally no treatment, appropriate adjustment of the mind, relieve the pressure can be relieved on their own. 2. Pyloric obstruction: common symptoms include nausea, vomiting, and vomit for hangover. Patients need to follow the doctor’s instructions for gastrointestinal decompression, suction out the contents of the stomach and intestines, if necessary, the use of gastric resection, gastrojejunostomy and other surgical treatment. 3. Peptic ulcer: the main symptoms are abdominal pain, nausea, anorexia, abdominal distension and so on. Patients need medical advice to apply bismuth such as bismuth potassium citrate, bismuth pectin and other bismuth agents, and proton pump inhibitors such as omeprazole, lansoprazole and so on. If Helicobacter pylori infection is present, eradication treatment should be carried out using the quadruple method, i.e., one proton pump inhibitor such as omeprazole + one bismuth agent such as bismuth pectin + two antibiotics such as amoxicillin and clarithromycin. For patients who develop serious complications and malignant peptic ulcers, surgical treatment such as major gastrectomy needs to be chosen. If the nausea in the middle of the night to rule out is caused by mental tension and other physiological factors, you should go to the hospital in time, clear the specific cause and then cooperate with the doctor for treatment.