There is no simplest way to determine HFMD. HFMD is an acute febrile rash disease caused by enteroviruses, and is mostly diagnosed through clinical manifestations and pathogenetic or serologic tests. 1. Clinical manifestations: To determine whether HFMD is present, the doctor will first observe the child’s clinical symptoms to see if the child has a rash on the hands, feet, mouth and other parts of the body, accompanied by fever, and usually has symptoms such as muscle weakness, irritability and poor mental health. 2. Pathogenetic examination: Nasopharyngeal swabs, airway secretions, herpes fluid or fecal specimens are positive for specific nucleic acids of enteroviruses such as CoxA16 and EV71, or enteroviruses can be isolated to confirm the diagnosis. 3. Serologic examination: serum CoxA16, EV71 and other enteroviruses neutralizing antibody is more than 4 times elevated can also confirm the diagnosis. If your child is suspected of having symptoms of HFMD, you should go to the hospital in time to be diagnosed by the doctor and take treatment to avoid delay in treatment.