Proteinuria in the early stage of chronic glomerulonephritis may turn negative after following the doctor’s instructions to actively standardize the treatment; however, if the treatment is not appropriate, there may be long-term non-transitional situation, or recurring proteinuria. Chronic glomerulonephritis is characterized by proteinuria, hematuria, hypertension, and edema, with different onset modalities and slow progression of the disease, with varying degrees of renal impairment, and some patients will eventually develop to end-stage renal failure. Most of them develop from primary glomerulonephritis of different causes, and a few of them develop from acute nephritis. Early glomerulopathologic changes are still relatively mild, a small amount of proteinuria can occur, urine protein is often 1 to 3g / d, at this time can be improved through active standardized treatment. Proteinuria is one of the important factors accelerating glomerulosclerosis. Clinically, angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists, such as Benadryl, Irbesartan and other drugs, are mainly used to reduce urinary protein or prompt it to turn negative, delaying renal function damage. However, there may be cases of persistent and recurrent urinary protein due to improper treatment. It is recommended that patients with chronic glomerulonephritis should seek medical treatment in time and take reasonable and standardized treatment under the guidance of professional doctors to avoid delaying the condition.