Low hemoglobin and high bilirubin may be caused by chronic hemolytic anemia, which can be treated by removing the cause of the disease, immunosuppressant and blood transfusion. 1. Removing the cause: If low hemoglobin and high bilirubin occur, the cause should be examined first. If it is caused by medication, the medication can be stopped first; if it is caused by viral infection, antiviral treatment can be carried out. 2. Immunosuppressants: Chronic hemolytic anemia caused by autoimmune diseases can be treated with immunosuppressants such as cyclosporine and cyclophosphamide. 3. Blood transfusion: If hemoglobin is so low as to be life-threatening, blood transfusion with washed red blood cells can be used for emergency treatment. If there is low hemoglobin and high bilirubin, you should consult a doctor in time, and relevant drugs should be used under the guidance of a doctor.