Duodenal ulcer usually does not lead to darkening of the face, darkening of the face is mostly seen in long-term sun exposure, endocrine disorders, liver function abnormalities and so on. Duodenal ulcer is a localized inflammatory defect caused by high gastric acid and pepsin invasion of the duodenal mucosa, with typical symptoms such as hunger pains and nocturnal pains, which are chronic and periodic. The disease does not usually result in darkening of the face. When the deepening of the ulcer destroys the submucosal blood vessels causing symptoms such as vomiting of blood and black stools, it can cause anemia manifestations such as pallor. Darkening of the face can be seen in a variety of circumstances, such as long-term exposure to sunlight, the impact of ultraviolet rays, aggravated melanin deposition resulting in darkening of the face. Endocrine disorders such as irregular work and rest, exhaustion and unhealthy diet can also cause darkening of the face. If the liver function is abnormal, the melanogenic hormone increases, which can lead to facial skin pigmentation, and the face looks dark and yellow. Darkening of the face can also be seen in endocrine diseases such as hypoadrenocorticism, etc. For specific cases, it is recommended to consult a doctor in time for diagnosis by a professional doctor.