If the high free thyroid hormone alone is caused by medication, no treatment is usually needed. If it is caused by hyperthyroidism, medication, radioactive iodine therapy, and surgery are required. There are many clinical reasons for high free thyroid hormone alone, which need to be treated according to the actual situation. If the high free thyroid hormone is caused by the use of amiodarone, sodium heparin and other drugs involved in the synthesis process of thyroid hormone, in general, no special treatment is needed, and regular rechecking of free thyroid hormone index is sufficient. However, if it is caused by hyperthyroidism, patients need to follow the doctor’s instructions to use propylthiouracil, methimazole and other anti-thyroid drugs, but also can use propranolol and other beta-blockers for adjuvant treatment. If long-term medication is ineffective and the condition is severe, thyroidectomy or radioiodine therapy should be considered. To summarize, patients with high free thyroid hormone need to cooperate with doctors to improve the relevant examinations and carry out corresponding treatment measures after clarifying the specific causes.