The possible diseases that cause constipation and blood in stool include inflammatory bowel disease, intestinal tuberculosis, hemorrhoids, anal fissure, intestinal tumors and other diseases. Different diseases are treated in different ways, which can be treated by medication, injection of sclerosing agents, sitz baths and even surgery. 1. Inflammatory bowel disease: including ulcerative colitis and Crohn’s disease, possible symptoms include diarrhea, constipation, blood in stool, abdominal pain and other symptoms. Inflammatory bowel disease is mainly treated with aminosalicylic acid preparations, such as sulfasalazine, which can effectively inhibit inflammatory mediators. If it is ineffective, hormones such as prednisone or immunosuppressants such as azathioprine can be used. 2. Intestinal tuberculosis: intestinal tuberculosis is a chronic infection of the intestinal tract caused by Mycobacterium tuberculosis, mainly with isoniazid, rifampicin and other anti-tuberculosis drugs. 3. Hemorrhoids: Hemorrhoids usually present with symptoms such as difficulty in defecation, blood in stool, pain after defecation, anal swelling and itching. The treatment of hemorrhoids can choose dietary modification, good defecation habits and other conservative treatment, if not effective, then need to be injected with sclerotherapy or surgical treatment. 4. Anal fissure: anal fissure often has periodic pain, blood in stool, constipation and other symptoms, commonly used liquid paraffin can make stool loose, improve constipation, also can use oxybutynin gel to reduce anal pain, potassium permanganate sitz baths to clean the perianal skin, auxiliary relaxation of anal sphincter. 5. Intestinal tumor: mainly colon cancer and rectal cancer, if it is an intestinal tumor, the most common treatment is surgery, but doctors need to judge whether it is operable according to the condition. If you have the symptom of constipation and blood in stool, it is recommended to go to the hospital in time to clarify the cause of the disease and take treatment under the guidance of the doctor.