Why does the hand hurt when infusing cephalosporin? This is because the infused cephalosporin liquid causes irritation to the endothelium of blood vessels, triggering an inflammatory reaction of the endothelium, which may spread to the peripheral membrane of blood vessels as well as to subcutaneous tissues, and so it will cause the symptom of hand pain. In order to prevent further aggravation of this condition, topical medications such as Xiliao-tu or heparin sodium ointment can be applied locally, which can usually reduce pain and control inflammation. If the pain is more pronounced, oral non-steroidal anti-inflammatory drugs such as ibuprofen or diclofenac sodium can also be taken to reduce pain and speed up the absorption of inflammation. If this is not possible, heat or physiotherapy can also be used to improve local circulation so that the inflammation can be absorbed as quickly as possible.