Non-invasive 13 high risk, it is also necessary to do amniocentesis to avoid misdiagnosis. The accuracy of non-invasive DNA test is very high, so non-invasive 13 high-risk can basically already determine that the fetus is a Down’s child, however, in order to avoid errors in the results, further amniocentesis is necessary, so that both tests are high-risk, and the diagnosis of Down’s child can be confirmed. Down’s babies are mainly characterized by low nasal bridge, wide eye spacing, mental retardation, inability to take care of themselves, etc. The prognosis is poor, so it is recommended that pregnant women should terminate the pregnancy promptly after diagnosis. In case of high risk of non-invasive 13, pregnant women should seek medical treatment for further examination in a timely manner so as to avoid delaying the condition, which may lead to an adverse pregnancy outcome.