Secondary liver cancer usually requires 4 to 8 cycles of chemotherapy, a course of about 21 or 28 days. Secondary liver cancer is a liver tumor that is secondary to other tumors, usually due to metastasis in the bloodstream or local spread. It usually manifests as weakness, poor appetite (poor appetite), jaundice, emaciation, and abdominal mass. The primary organs are mostly found in the stomach, biliary tract, pancreas, colorectum, ovaries, and uterus. If the diagnosis is secondary to the tumor, a combination of treatments may be used. Chemotherapy is one of the means, and commonly used chemotherapeutic agents include anthracycline antibiotics, paclitaxel, 5-fluorouracil and vincristine. The specific cycles of chemotherapy are related to the chemotherapy regimen, the patient’s condition, and the post-treatment response, and usually 4-8 cycles are needed. The purpose of chemotherapy is to prolong the patient’s survival time, improve pain, and enhance the quality of survival. If secondary liver cancer is diagnosed, patients should actively seek medical treatment and standardize the treatment under doctor’s guidance to improve the disease prognosis.