The 52-year-old Mr. Wang is a sales manager of a company, usually socialize a lot, recently always feel upset stomach, thought that the “stomach disease”, so in the drugstore to buy some stomach medicine, eat a period of time, feel better. After two months, he felt uncomfortable again. At the urging of his family, Wang went to the hospital’s gastroenterology department and had a gastroscopy, which revealed chronic superficial gastritis. So Mr. Wang put off unnecessary social engagements and took his medication as prescribed by the doctor. But two months down the road, the symptoms still keep recurring, and also lost a lot of weight. The tumor index CA 19-9 was found to be high and he suspected that it was a tumor of the pancreas. Further CT of the upper abdomen revealed a huge tumor in the tail of the pancreatic body, and metastases were also found in the liver, thus losing the precious opportunity of surgery. Pancreatic cancer is an insidious, extremely dangerous and highly malignant tumor of the digestive tract. In particular, the symptoms of pancreatic tail cancer tend to be more insidious, and the mass is larger when it is detected, and distant metastases are likely to have already occurred. In the United States, pancreatic cancer ranks as the fourth most common malignant tumor death. In China, pancreatic cancer has become one of the top ten malignant tumors that kill the population. With the improvement of people’s living standard and the change of diet structure and living habits, the incidence of pancreatic cancer in China is increasing year by year. In recent years, the overall incidence of malignant tumors in Shanghai has been decreasing, but the incidence of pancreatic cancer has been increasing significantly, ranking eighth in the city in terms of malignant tumors and sixth in terms of mortality. The diagnosis of pancreatic cancer mainly relies on clinical manifestations and imaging. Early discomfort in the upper abdomen due to increased pressure in the lumen caused by pancreatic duct obstruction is a common first symptom of pancreatic cancer, but due to its non-specific nature, it is often easily mistaken for a gastrointestinal disease. Since most of the patients are middle-aged and elderly, some of them, like Mr. Wang, usually have a lot of social functions, can easily be treated as chronic gastritis, and because chronic gastritis has a prolonged course and is prone to recurrence, there are few patients who consider pancreatic cancer only when symptoms such as jaundice, emaciation and back pain appear. Therefore, clinically, when the above-mentioned conditions occur, one should be alert and consider whether it is caused by pancreatic cancer. What are the examination methods for pancreatic cancer? For patients with clinical suspicion of pancreatic cancer and those at high risk of pancreatic cancer, non-invasive tests should be preferred for screening, such as ultrasound, CT and serological tumor markers. Combined testing of tumor markers (such as CA 19-9, etc.) and combined with imaging results can increase the positive rate and help in the diagnosis and differential diagnosis of pancreatic cancer. What are the treatments for pancreatic cancer? The main methods of pancreatic cancer treatment include surgery, chemotherapy, radiotherapy and biotherapy. Radical surgery is still the only effective cure for pancreatic cancer, but it is complicated, traumatic and has a high complication rate. Currently, individualized treatment and multidisciplinary comprehensive treatment are implemented clinically, which can improve the treatment effect and long-term survival rate of pancreatic cancer. (1) Age greater than 40 years with non-specific discomfort in the upper abdomen; (2) Family history of pancreatic cancer; (3) Sudden onset of diabetes mellitus, especially atypical diabetes mellitus, age 60 years or older, lack of family history, no obesity, and soon developing insulin resistance. 40% of pancreatic cancer patients have diabetes mellitus at the time of diagnosis; (4) Patients with chronic pancreatitis, currently it is believed that chronic (4) Patients with chronic pancreatitis are now considered to be an important precancerous lesion in a small number of patients, especially chronic familial pancreatitis and chronic calcific pancreatitis; (5) Intraductal papillary mucinous neoplasm is also a precancerous lesion; (6) Patients with familial adenomatous polyposis; (7) Patients with benign lesions who underwent major distal gastrectomy, especially those who are more than 20 years postoperative; (8) High risk factors for pancreatic cancer include long-term smoking, heavy alcohol consumption, and long-term exposure to harmful chemicals. and long-term exposure to harmful chemicals.