Pain in the liver area caused by liver tumors has a certain correlation with the size of the specific tumor, but it is not directly related to it, and the cause of pain is mainly due to the compression and irritation of the hepatic peritoneum. With the growth of liver tumor, it may compress and invade the hepatic peritoneum, which will further lead to the symptoms of pain and discomfort in the liver area. There is no direct correlation between liver pain and the size of the lesion. Some tumors, even if small in size, are located at the edge of the liver, which may cause pericardial irritation and pain; however, the larger the size of the tumor, the greater the probability of causing pain. When liver tumor is found to cause obvious pain in the liver area, accompanied by localized mass and decreased liver function, it is necessary to consult a doctor in time for examination, and carry out standardized treatment under the guidance of clinicians after diagnosis of the disease.