For those who cannot undergo bypass surgery for all three major blood vessels of the heart, other surgical treatments, medications, etc. can be performed as prescribed by the doctor, and general nursing care should also be strengthened. For those who have total blockage of the three major blood vessels of the heart and cannot undergo heart bypass surgery, coronary stenting, heart transplantation and other surgical treatments can be chosen after a comprehensive assessment by the doctor, which can help to improve the function of the heart and alleviate the uncomfortable symptoms caused by the disease. Contraindications need to be screened before surgery to prevent unforeseen circumstances. In addition to surgical treatment, some patients may be treated with lipid-regulating drugs such as atorvastatin and simvastatin, antiplatelet drugs such as aspirin and clopidogrel, thrombolytic drugs such as streptokinase and alteplase, and anticoagulant drugs such as low-molecular-weight heparin and warfarin, as prescribed by the doctor. Some patients may also be treated with angiotensin-converting enzyme inhibitors such as captopril and enalapril. It is recommended that those who have the three major blood vessels of the heart completely blocked and can not do heart bypass surgery should follow the doctor’s instructions for treatment, and should not indiscriminately use drugs or prescriptions on their own. Take rest, avoid strenuous exercise, pay attention to the balanced intake of nutrients, and consult a doctor for regular checkups.