Pressing pain in the middle of the front of the calf can be caused by trauma, muscle strain, periostitis, infection and other factors, and general, physical, drug and surgical treatment is feasible. 1. Trauma: Trauma to the middle part of the front of the calf can cause local bone and soft tissue injury, and pressure pain symptoms can occur. Attention should be paid to the affected area to brake and rest, the acute stage can be treated with local cold compresses, oral ibuprofen and other drugs as prescribed by the doctor for analgesia, but also the application of flurbiprofen ester cream external treatment, fractures and other serious injuries need to be treated with surgery. 2. Muscle strain: prolonged over-exertion and exposure to cold in the calf can lead to local muscle strain and aseptic inflammation, which can cause pain symptoms. It is necessary to pay attention to leg rest and keep warm, can be in the regular hospital massage, hot packs, massage and other treatments. 3. Osteochondritis Dissecans: Osteochondritis Dissecans of the tibiofibular bone can cause pressure and pain in the middle of the front part of the calf, accompanied by swelling and other manifestations. Under the guidance of the doctor, oral anti-inflammatory and analgesic drugs such as celecoxib can be used, and local hot compresses can be applied to accelerate blood circulation and promote the dissipation of inflammation. 4. Infection: Infection of the skin and soft tissues in the middle of the front of the calf can cause redness, swelling, heat and pain and other inflammatory symptoms. Need to consult a doctor to clarify the infection, can be applied under the guidance of the doctor amoxicillin, cefixime and other antibiotic treatment, and need to be regular local drug change. When the middle of the front of the calf pressure pain, you need to consult a doctor in time, under the guidance of specialists to actively carry out appropriate treatment, will help to relieve the symptoms of discomfort early.