The most common disease that occurs with leg pain symptoms after drinking liquor is gouty arthritis, in which patients suffer from hyperuricemia due to abnormal purine metabolism or impaired elimination of uric acid from the blood. Blood uric acid increases abnormally after heavy alcohol consumption and uric acid crystals appear around the joints, thus triggering an acute inflammatory reaction in the soft tissues, manifesting as redness, swelling, heat and pain around the joints. The onset of the disease is often acute, and patients are often awakened by pain in the early morning with more intense symptoms. In the acute stage, the treatment is mainly oral non-steroidal anti-inflammatory and analgesic drugs, COX-2 inhibitors, such as etoricoxib, and after the symptoms are relieved, patients need to consult the endocrinology or rheumatology department for regular treatment to control blood uric acid.