An albumin-to-globulin ratio of less than 1.5 is indicative of a more serious condition, but the severity of the condition needs to be assessed based on the albumin and globulin values. The albumin-to-globulin ratio is the ratio of albumin to globulin, with a normal range of 1.5 to 2.5, and can decrease when albumin decreases and/or globulin increases. Albumin is synthesized by liver cells. When liver diseases such as hepatitis, hepatocellular carcinoma, cirrhosis, etc. occur, the synthesized albumin decreases, which can lead to a decrease in the white globule ratio. When the white globule ratio is lower than 1.5, it suggests that the body may have a more serious liver impairment and the condition is more serious. In addition to liver disease, malignant plasma cell diseases such as multiple myeloma and Wahl’s macroglobulinemia can lead to a significant increase in globulin and a decrease in the white globulin ratio. Therefore, the albumin and globulin values need to be integrated to analyze the condition. It is recommended that the patient consult a doctor in time, complete the relevant examination to clarify the cause of the decrease in white globule ratio, and then target the cause of the treatment.