Generally there is no need to apply medicine after picosecond laser spot removal, but if secondary infection occurs, antibiotics and other medicines can be applied as prescribed by the doctor. Picosecond laser spot removal is to make use of the photothermal effect of laser to break the pigment particles, and then promote the absorption and metabolism of pigment to achieve the effect of spot removal. Usually, there is no need to apply medicine after picosecond laser. You need to do a good job of daily protection, avoid scratching, rubbing the affected area, but also pay attention to a light diet, as little as possible to eat spicy and stimulating food, etc., in order to facilitate the repair of laser treatment. If there is local redness, swelling and other secondary infections after laser treatment, you can apply mupirocin, fusidic acid and other antibiotic drugs for anti-infection treatment, which will help recovery. After picosecond laser spot removal, it is recommended to go to the regular medical institutions, consult with specialists on related matters, if abnormalities occur, you should go to the regular hospital for follow-up, and under the guidance of the doctor’s treatment, do not use drugs without authorization, so as not to cause adverse consequences.