Boils on the legs can be treated with anti-inflammatory and antibacterial ointments such as clindamycin phosphate gel, fusidic acid cream, and mupirocin ointment. Boils are mainly caused by Staphylococcus aureus infection, causing acute bacterial purulent inflammation of individual hair follicles or surrounding tissues, and in a few cases, by staphylococcus, streptococcus, and Escherichia coli, either alone or in combination. The condition can be treated with medication in milder cases, while severe suppuration requires incision of the lesion to drain the pus. Therefore, antimicrobial creams should be used to treat boils. Clindamycin phosphate gel, fusidic acid cream, and mupirocin ointment are antibiotic medications that are effective against infections caused by various gram-positive bacteria such as staphylococcus and streptococcus. To summarize, patients when boils appear should keep the affected area clean and use medication under the supervision of a doctor.