ICC is an abbreviation for intrahepatic cholangiocarcinoma, which is a type of primary hepatocellular carcinoma. The malignancy and lethality of primary liver cancer are relatively high. In addition to ICC, there are other types such as hepatocellular carcinoma (HCC) and mixed hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA), of which ICC is relatively rare, accounting for about 10%-15%.1. Typing: Histologically, ICC can be divided into bold ductal type and small bile duct type. The large bile duct type ICC originates from above the septal bile ducts of the hepatic lobules to the larger bile ducts between the adjacent hilar region, with large and irregular caliber of the glandular ducts. The small bile duct type of ICC originates in the small bile ducts or small bile ducts below the septal bile ducts of the lobules of the liver, and the glandular ducts are small and regular in caliber or may appear as solid, thin cords with closed lumen. Studies show that the clinical prognosis of patients with small bile duct type is better than bold duct type. 2. Clinical manifestations and treatment: Similar to hepatocellular carcinoma, ICC patients have insidious onset and early symptoms are not obvious. When obvious symptoms appear, mainly including pain in the liver area, loss of appetite, weakness, wasting and liver size, etc., they are usually in the middle and late stages of cancer. If jaundice appears, most of them are already in advanced stage. ICC patients are mainly detected by physical examination in early stage, and timely surgical treatment can achieve better results, while radiation and local treatment can be considered in the middle stage, etc. In the late stage, usually only chemotherapy can be administered to improve symptoms.