Leukemia bone pain tends to be characterized by swelling, and in some patients the pain can also be sore. Skeletal pain in leukemia is usually more severe, and milder pain medications are often less effective, requiring the application of pain management such as morphine. For leukemia bone pain, it is necessary to clarify whether the patient is tumor pain, or pain caused by the application of granulocyte colony-stimulating factor, blood abnormal rebound. If the pain is tumorigenic, it is necessary to actively treat the primary disease, carry out chemotherapy, and reduce the tumor load. If the pain is caused by an abnormal rise in granulocytes due to the application of granulocyte colony-stimulating factor, the granulocyte colony-stimulating factor needs to be discontinued.