There are many reasons for walking pain in the ball of the foot, such as long-distance walking foot overload, plantar fasciitis, heel bone bursitis, etc., should be directed to the cause of drug treatment. 1. Long-distance walking foot overload: long-distance walking or walking for too long will cause foot overload, causing pain in the ball of the foot. In this case, you can soak your feet in hot water or apply hot compresses, and if the pain is obvious, you can use topical or oral painkillers, such as diclofenac aerosol, Yunnan Baiyao spray, ibuprofen and so on. 2. Plantar fasciitis: aseptic inflammation of the plantar fascia due to repeated micro-injuries, mainly manifested as pain in the medial part of the front of the heel. This situation should pay attention to rest, can be ice packs. The most commonly used medications are non-steroidal anti-inflammatory drugs (such as acetaminophen, ibuprofen, celecoxib) and corticosteroids. 3. Heel bursitis: Excessive pressure or irritation of the heel bursa leads to inflammation and the formation of bursitis. This condition can be treated with topical or oral non-steroidal anti-inflammatory drugs, such as diclofenac aerosol, ibuprofen, and acetaminophen. You can also take some Chinese medicines that have the effect of activating blood circulation and removing blood stasis, such as Panax ginseng tablets. The above medicines should be chosen according to the individual’s situation under the guidance of a doctor.