The skeleton generally does not become wider in middle age, and if it does, it often suggests that it is suffering from osteoarthritic diseases. Humans generally to the age of 18, the latest 24 years old, except for special circumstances, with the epiphysis of the closure of the bones stop growing, the skeleton also stop changing, after 40 ~ 50 years, after old age, with the occurrence of osteoporosis, the body muscle atrophy, the skeleton may become smaller. For the widening of the skeleton, osteoarthritis, rheumatoid arthritis or gouty arthritis may occur. These diseases often have enlargement of the bone and joints, which will result in a widening of the skeleton, often accompanied by pain, swelling, limitation of movement, and even deformity of the joints, such as inversion or eversion deformity of the knee joint. For deformed joints, artificial joint replacement surgery should be considered. If there are changes in the skeleton of a person in middle age, and if accompanied by uncomfortable symptoms, it is recommended to actively consult the doctor, complete the relevant examinations, and carry out targeted treatment under the guidance of the doctor after clarifying the cause of the disease, so as to avoid delays in the condition.