It is possible for Creatinine 619umol/L to return to normal, which needs to be analyzed according to the cause of the patient’s illness. If the patient is due to acute renal failure caused by drug stimulation or other elements and creatinine 619umol/L occurs, after timely and effective treatment, usually can return to normal. If the patient’s creatinine 619umol/L is caused by chronic kidney disease, chronic renal insufficiency and other diseases, it means that the kidney function has been damaged, which is irreversible, so it can not return to normal. In order to prevent the condition from progressing and creatinine continue to rise, patients with chronic kidney disease should control the risk factors such as blood pressure, blood glucose, and blood lipids on the basis of treating the primary foci. At the same time, attention should be paid to low-salt, low-fat, high-quality and low-protein diet. It is recommended that patients with abnormal creatinine should go to the hospital in time, clarify the cause of the disease under the guidance of doctors, and actively treat the disease to avoid delay.