A wart on the hand is also known as common wart, which is a benign skin growth caused by human papillomavirus infection, manifesting itself as a mung bean, soybean-sized or larger pimple with a hard texture and rough surface. Patients with more limited rashes may consider topical treatment, and commonly used topical medications include salicylic acid, 5% 5-fluorouracil ointment, retinoic acid ointment, and 5% imiquimod cream. Physical therapy includes curettage, freezing, carbon dioxide laser, and microwave therapy. In addition, intradermal injections, such as bleomycin intra-wart injections until the rash whitens, are more effective in the treatment of recalcitrant common warts. If the rash is generalized and topical medications are not effective, systemic treatment can be considered, and immunomodulators, such as levamisole, transfer factor, interferon, etc., can be tried.