Foot gout may be caused by heredity, disease, drugs and excessive production of organic acids. 1. Heredity: primary gout may be genetically related, mainly seen in hypoxanthine guanine phosphoribosyltransferase deficiency or phosphoribosylpyrophosphate synthase activity increases, which can increase uric acid production in the body. 2. Diseases: Kidney diseases and blood system diseases may lead to secondary gout, such as erythrocytosis, hemolytic anemia, lymphoma, renal tubular disease, etc., respectively, through the increase of uric acid production and uric acid excretion obstruction and other pathways in the body of uric acid elevated and thus lead to gout. 3. Drugs: rifampicin, pyrazinamide, low-dose aspirin and tacrolimus, azathioprine and other immunosuppressants, furosemide, hydrochlorothiazide and other diuretics can cause uric acid reabsorption through the renal tubules to increase the excretion of uric acid impeded and lead to gout. 4. Excessive organic acid production: lactic acidosis, diabetic ketoacidosis can lead to excessive organic acid production in the body, can inhibit uric acid excretion and cause gout. In addition, there are some gout cause is not yet clear, it is recommended that gout patients to the regular hospital rheumatology and immunology department for further diagnosis, and comply with the prescribed treatment.