Acne on both sides of the cheeks can be a symptom of medication or other factors, but it can also be a symptom of acne, folliculitis or other diseases. Patients with acne on both sides of the cheeks should go to the hospital to find out the cause of the problem. 1.. Drugs: long-term use of antiepileptic drugs such as phenytoin sodium, hydrocortisone and other corticosteroids can also cause patients to develop symptoms of acne on both sides of the cheeks. 2. Acne: Acne is an inflammatory skin disease caused by abnormal secretion of sebaceous glands and Propionibacterium acnes infection, etc. Acne can cause patients to develop inflammatory papules, nodules, cysts and other symptoms. Therefore, acne can lead to acne on both sides of the cheeks. 3. Folliculitis: Folliculitis is an inflammatory skin disease that mainly involves hair follicles. It mainly occurs on the scalp, face, buttocks and thighs. The patient’s lesions are mainly manifested as red papules or pustules centered on hair follicles, which can be accompanied by itching and pain and other symptoms. Therefore, folliculitis can lead to acne on both sides of the cheeks. Patients with acne on both sides of the cheeks should go to the hospital in time, identify the cause of the disease under the guidance of the doctor, and treat the symptoms.