Increased urinary protein can be caused by physiological factors or pathologic factors. Physiological factors are mainly in the urine routine examination before the late night or fever, these conditions may lead to a transient increase in the permeability of the renal filtration membrane, will be detected in the urine routine urine protein, but the amount of this protein is relatively small, in the urine routine examination found in the urine protein between (+-) to (+). If it exceeds (++), it can’t be considered to be caused by physiological factors, but should be considered to be caused by pathological factors, the most common pathological factors are various kinds of nephritis, with chronic nephritis being the most common, and other secondary nephritis such as lupus nephritis, purpuric nephritis, hepatitis B virus-associated nephritis, etc., which are also relatively common, and it is necessary to improve the antinuclear antibody spectrum, virus-related tests to further distinguish what kind of nephritis it is. It is necessary to improve the antinuclear antibody profile, virus-related tests to further distinguish the type of nephritis, and then decide the next step of the treatment program.