Heavy fluid in the abdomen after chemotherapy for colon cancer can be treated with drainage and medication through peritoneal puncture placement. In addition, it is also necessary to continue anti-tumor treatment. 1. Peritoneal puncture and tube drainage: If colon cancer patients have severe fluid accumulation in the abdominal cavity after chemotherapy, surgical puncture is feasible to drain the fluid. By puncturing the abdominal cavity and placing a drainage tube, the fluid accumulated in the abdominal cavity can be released, which can restore the patient’s intestinal function and alleviate the influence of fluid accumulation on cardiopulmonary function, and relieve the symptoms of abdominal pain and bloating. 2. Medication: In the case of heavy fluid accumulation in the abdominal cavity, furosemide, aminopterin, spironolactone and other diuretics may be used as appropriate depending on the patient’s individual condition and the results of other auxiliary tests to assist the patient’s body in discharging the fluid. There may also be hypoproteinemia, the need to supplement protein drugs need to be used under the guidance of a physician. 3. Anti-tumor therapy: chemotherapy drugs can be used to kill cancer cells, which may reduce the accumulation of fluid in the abdominal cavity. The above treatments should be operated by doctors in regular hospitals, and it is not recommended for patients to take medicines and treatments by themselves, and it is recommended for patients to actively cooperate with doctors in order to avoid adverse consequences.