Patients with fire and blistering at the corners of the mouth are caused by herpes simplex virus type 1 infection, which is related to the patient’s low immunity, overwork and poor rest, as follows: 1. Viral infection: local topical drugs, topical acyclovir or penciclovir and other antiviral infection drugs are needed, after topical application, to relieve pain, burning, discomfort and other symptoms, but also to shorten the course of the disease. 2. Bacterial infection: some After the patient’s mouth blisters, local combined with bacterial infection, redness, swelling, pain will be more serious, there will also be pus oozing, then you need to combine the anti-bacterial infection drugs applied externally, commonly used such as fusidic acid cream or compound polymyxin B ointment to kill bacteria. If necessary, you can also combine antiviral medications, such as vaxilovir hydrochloride and famciclovir orally.