Postoperative pathology t2m0n0 of esophageal cancer mostly belongs to stage II of esophageal cancer, if not actively treated, the condition may progress rapidly, so it should be highly valued. Postoperative pathology of esophageal cancer t2n0m0 indicates that the tumor cells have invaded the intrinsic muscle layer, but there is no lymph node and distant metastasis, and it mostly belongs to stage Ⅱ. During this period, the patients are mostly treated by surgery, and after surgery, according to the condition of the patients, the patients are assisted with radiotherapy and chemotherapy, etc. The 5-year survival rate of esophageal cancer in stage Ⅱa is 70%~85%, and that of stage Ⅱb is 45%~67%. Whether esophageal cancer is serious or not is also related to the differentiation degree of cancer cells and whether there is vascular thrombus. The prognosis is generally not good if the cancer cells are poorly differentiated and there is vascular thrombus. In addition, if the patient is in good physical condition, young, with proper treatment and good drug sensitivity, he/she may have a good prognosis. It is suggested that patients should choose the appropriate treatment plan according to their comprehensive situation under the guidance of doctors and adhere to the treatment.