Toothache is the main symptom of endodontic periapical disease, wisdom tooth pericoronitis can also be caused, want to reduce the pain without medication can be medical treatment, the doctor according to the situation to take jaw adjustment and grinding, remove the irritation, anti-inflammatory pain relief and so on. If necessary, you should follow the doctor’s instructions to use medication. 1. Adjustment and grinding: acute apical periapical inflammation caused by trauma, should lower the bite, reduce the affected tooth force. 2. Remove the stimulus: root canal trauma and chemical stimulation caused by periapical inflammation, the stimulus should be removed, repeated rinsing of the root canal, re-seal the drug, or seal the sterile cotton twist, to avoid re-infection. 3. Anti-inflammatory pain relief: Oral painkillers such as ibuprofen and sodium lorsoprofen tablets can be used, or antibacterial drugs such as metronidazole and ornidazole, etc. Local closure is also available. All of the above can be used to reduce the symptoms of toothache, but can not cure the toothache, the specific use of which way, whether you need to take medication to follow the doctor’s advice. If you want to cure it, you need to find out the cause of the problem and treat it. Medications should be used under the direction of a doctor.