The role of probenecid can be used for patients with hyperuricemia, chronic gouty arthritis, and gouty stones, and can also be used as an adjunct to antibiotics to improve the efficacy of antibiotics. Probenecid works by inhibiting the active reabsorption of urate in the proximal tubules of the kidneys and increasing the excretion of urate, thus reducing the concentration of urate in the blood. Gastrointestinal reactions such as nausea, vomiting loss of appetite may occur after the use of probenecid, and adverse reactions such as dizziness, headache, flushing of the face, rash, itching of the skin may also be seen, if the adverse reactions are serious and cannot be relieved by themselves, please consult a doctor for treatment promptly. Probenecid should not be used concurrently with salicylic acid drugs, aspirin, etanercept, hydrochlorothiazide and other drugs, because this product can inhibit the excretion of these drugs in the renal tubules, so that the effect is enhanced and the toxicity increased. The use of probenecid needs to follow the doctor’s advice, not self-administration, renal hypoplasia patients, sulfonamides allergy and renal insufficiency patients are prohibited.