Estrogen preparations can be used in moderation during menopause if there are symptoms such as hot flashes, night sweats, sleep disturbances, and vaginal dryness, after excluding contraindications such as suspected breast cancer. During menopause if there are symptoms related to menopause such as hot flashes, night sweats, sleep disorders, problems related to genital tract atrophy such as vaginal dryness, recurrent vaginitis, and osteoporosis, estrogen supplementation can be used to alleviate the symptoms, but relevant contraindications must be ruled out. Contraindications to estrogen supplementation therapy include pregnancy, unexplained vaginal bleeding, suspected breast cancer, suspected sex hormone-dependent malignancy, and an arterial thromboembolic event within the last 6 months. Estrogen should also be used with caution in the presence of uterine fibroids, endometriosis, uncontrolled diabetes mellitus, severe hypertension, and thrombotic tendencies. Side effects of estrogen therapy may include breast swelling and pain, headache, edema, etc. Long-term use may also increase the risk of breast, endometrial, and ovarian cancers, so be sure to use it cautiously under the guidance of a doctor, and don’t arbitrarily increase the dosage or prolong the duration of the medication.