The 10 times over normal value of alanine aminotransferase may be due to viral hepatitis, drug hepatitis, hepatocellular carcinoma and other causes of severe impairment of liver function or even liver failure, which can be treated by taking antiviral drugs such as entecavir and other liver-protecting drugs such as adenosylmethionine and, if necessary, by artificial liver or surgery. 1. Viral hepatitis: Acute viral hepatitis will lead to liver cell damage and destruction, and the release of alanine aminotransferase into the blood, causing alanine aminotransferase to rise 10 times higher than the normal value. It can be treated by taking antiviral drugs such as entecavir and lamivudine, and at the same time giving liver-protecting drugs such as adenosylmethionine and glycyrrhizic acid. 2. Pharmacological hepatitis: taking isoniazid, rifampicin and other drugs may damage the liver, leading to destruction of liver cells, and cause alanine aminotransferase to rise 10 times higher than the normal value. Drugs that cause drug-induced hepatitis should be stopped in time, and at the same time, liver-protecting drugs such as acetylcysteine and reduced glutathione should be used in conjunction with the treatment, and artificial liver treatment is feasible if the symptoms are serious. 3. Hepatocellular carcinoma: Hepatocellular carcinoma patients may suffer from liver cell damage due to tumor cells invading normal liver tissues, which may cause alanine aminotransferase to rise 10 times higher than normal. It can be treated by partial hepatectomy, hepatic artery chemoembolization and other surgical procedures. If the alanine aminotransferase is 10 times higher than normal, you should go to the hospital in time to improve the examination and give targeted treatment after clarifying the cause of the disease.