If cholangiocarcinoma has metastasized to peripheral lymph nodes, depending on the scope of spread of the lesion, radical surgery combined with chemotherapy is adopted as the treatment plan, or chemotherapy, targeted therapy, radiotherapy and other treatments are given as a comprehensive strategy. If cholangiocarcinoma has metastasized to peripheral lymph nodes, patients who are able to undergo surgery should try their best to undergo radical surgery for cholangiocarcinoma combined with regional lymph node dissection, and be given 4~6 cycles of adjuvant chemotherapy after surgery. For patients with peripheral lymph node metastasis and wide dissemination of lesions that cannot be treated by radical surgery, the comprehensive treatment strategy of chemotherapy combined with radiotherapy will be adopted. For some patients with peripheral lymph node metastasis of cholangiocarcinoma with gene mutation, targeted drugs are usually chosen for treatment. For patients with peripheral lymph node metastasis of cholangiocarcinoma, it is recommended to consult hospitals as early as possible for standardized diagnosis and treatment by professional doctors.